The NFL standings have begun to take shape with two weeks down in the NFL season, and it is now time to look ahead at your Week 3 NFL predictions.
Whether you are looking to make NFL Week 3 predictions against the spread, on the moneyline, or with Sportzino’s countless player prop options, you have found the right place for your NFL predictions.
Let’s dive in.
NFL Week 3 Predictions and Picks
Game 1: Green Bay Packers at Cleveland Browns
Sunday, September 21st, 1:00 PM EST
- Moneyline: Packers -450, Browns +285
- Spread: Green Bay Packers (-7.5)
- Total: 42.5 Points
The Cleveland Browns are significant home underdogs against the Packers this week. However, the best prediction you can make is not on either team, but rather the total staying under the current live odds.
Cleveland’s offensive woes have been thoroughly documented, and it has overshadowed decent play on the defensive side of the ball. Green Bay has a methodical offense that lacks explosive plays down the field, and they will struggle to run up the score.
On the other side of the ball, the Packers have flashy new signing Micah Parsons to cause havoc for Joe Flacco. Green Bay extinguished the red-hot Lions and Commanders, and there is no reason to expect points on the board for the Browns. This is a lower-than-average total for your Week 3 NFL predictions, but the under is still absolutely the way to go.
Pick: Under 42.5 Points -125
Game 2: Los Angeles Rams at Philadelphia Eagles
Sunday, September 21st, 1:00 PM EST
- Moneyline: Rams +140, Eagles -200
- Spread: Philadelphia Eagles (-3.5)
- Total: 44.5 Points
The defending Super Bowl champions are off to a 2-0 start this season and have shown no signs of slowing down.
Los Angeles squeaked by the lowly Titans and Texans, and this is a massive step up in competition. Philadelphia brings a physical style of football to the field that few teams are able to match, and an aging Rams offense will struggle to keep up.
The NFL odds expect this one to be a close game, but it is impossible to agree. Take the Eagles to win by at least four points for your Week 3 NFL prediction, as more often than not, Philly will win by double digits.
Pick: Philadelphia Eagles (-3.5) -115
Game 3: New Orleans Saints at Seattle Seahawks
Sunday, September 21st, 4:05 PM EST
- Moneyline: Saints +260, Seahawks -400
- Spread: Seattle Seahawks (-7.5)
- Total: 41.5 Points
The New Orleans Saints may go all season without winning a game. Their offense is inconsistent, their defense is generous, and the lack of game changers on this roster has capped their playoff hopes. Despite those facts, the Saints should not be touchdown underdogs against a team like Seattle.
The Seahawks needed a special teams miracle to beat the Steelers last week after they came out flat in Week 1. Sam Darnold in the favorite role has not been an effective NFL prediction over the years, and that is unlikely to change anytime soon. This will be an ugly game to watch, but the NFL odds give us no choice but to plug our noses and take the generous amount of points against the spread.
Pick: New Orleans Saints (+7.5) -125


NFL Player Prop Predictions: Miami Dolphins at Buffalo Bills
Thursday, September 18th, 8:15 PM EST
- Moneyline: Dolphins +450, Bills -900
- Spread: Buffalo Bills (-12.5) -120
- Total: 49.5 Points
Josh Allen is a one-man wrecking ball, and he will bulldoze his way into the end zone on Thursday night. Miami is a team that can’t contain explosive offenses between the 20s, and once Allen sees the end zone, he will hurl his body into it. He ran in for two touchdowns against Baltimore in the season opener, and it is a much easier task to get into the red zone.
Pick: Josh Allen to score 2+ touchdowns +300
NFL Score Predictions: Indianapolis Colts at Tennessee Titans
Sunday, September 21st, 1:00 PM EST
- Moneyline: Colts -210, Titans +150
- Spread: Indianapolis Colts (-3.5)
- Total: 43.5 Points
Daniel Jones has been electric for the Colts this season, and we are in store for a shootout in Tennessee this weekend. Both of these teams will let their young signal callers loose, and the endzone shots will be plentiful Sunday afternoon. The 4.5 touchdown line has been cleared by the Colts in both games this season, and there is no reason to doubt that trend now.
Pick: Total Touchdowns: Over 4.5 -160
For more expert breakdowns, check out our NFL Week 2 Predictions
NFL Moneyline Predictions: Denver Broncos at Los Angeles Chargers
Sunday, September 21st, 4:05 PM EST
- Moneyline: Broncos +115, Chargers -160
- Spread: Los Angeles Chargers (-2.5)
- Total: 45.5 Points
Denver has been able to win football games without playing their best on the field, and that is exactly what we are looking for with NFL odds like these.
Their gritty play on both sides of the ball will be tested against the 2-0 Chargers, and they will pass with flying colors. Justin Herbert has been perfect so far, but when he inevitably regresses, the Broncos will pounce at the opportunity.
Pick: Denver Broncos Moneyline +115


NFL Against the Spread Predictions: Las Vegas Raiders at Washington Commanders
Sunday, September 21st, 1:00 PM EST
- Moneyline: Raiders +140, Commanders -200
- Spread: Washington Commanders (-3.5)
- Total: 44.5 Points
Jayden Daniels is questionable to play in this one, which will obviously have a huge impact on this game. Even without their star quarterback, there is no reason to overlook the Commanders with this short line.
The Las Vegas offense is a mess with Geno Smith under center, and there is no light at the end of the tunnel for the Raiders. Washington will rally on defense to overcome any offensive shortcomings and will cover the spread in the process.
Pick: Washington Commanders (-3.5) -120




