The college football season continues to march on as the rankings begin to take shape heading into the fourth week of the season.
There wasn’t too much movement last week in the rankings, but everything is to play for this weekend. The college football odds have been released, and there has never been a better time to make your free college football week 4 predictions.
These early-season matchups can make or break a school’s chance at making the college football playoff in a few months, and there is no shortage of tangible rewards on the line.
Who will rise in the rankings and who will plummet into irrelevancy? Only one way to find out as we jump into the college football predictions for week 4.
College Football Week 4 Odds
The college football week 4 odds are now live, and there are several tantalizing matchups to choose from.
The wide point spreads allow you to make week 4 college football predictions on every single NCAA football game this week. The NCAAF odds are quite wide for some ranked vs. unranked meetings, but don’t be deterred.
Using the expert college football predictions provided below, you can confidently navigate the upcoming slate of games.
| Matchup | Spread | Moneyline | Over/Under |
| Texas Tech at Utah | Utah -3.5 (-120) | TEX +140/UTA -210 | 57.5 |
| UAB at Tennessee | Tennessee -40.5 (-110) | UAB +900 | 67.5 |
| Oregon State at Oregon | Oregon -35.5 (-115) | Oregon State +900 | 57.5 |
| Auburn at Oklahoma | Oklahoma -5.5 (-140) | AUB +180/OK -275 | 48.5 |
| Tulane at Ole Miss | Ole Miss -12.5 (-115) | TUL +300/OLE -550 | 60.5 |
| Michigan at Nebraska | Michigan -2.5 (-120) | MICH -145/NEB +100 | 44.5 |
| Purdue at Notre Dame | Notre Dame -26.5 (-120) | Purdue +900 | 55.5 |
| South Carolina at Missouri | Missouri -13.5 (-120) | SC +350/MIZ -650 | 46.5 |
| Florida at Miami | Miami -7.5 (-120) | FLO +220/MIA -350 | 52.5 |
| Illinois at Indiana | Indiana -4.5 (-115) | ILL +140/IND -210 | 52.5 |
| Sam Houston at Texas | Texas -40.5 (-120) | Sam Houston +1000 | 51.5 |
| Michigan State at USC | USC -16.5 (-135) | MSU +425/USC -900 | 56.5 |
College Football Week 4 Odds Analysis
(#17) Texas Tech at (#16) Utah
- Spread: Texas Tech +3.5, Utah -3.5
- Moneyline: Texas Tech +140, Utah -210
- Over/Under: 57.5 Points
- Time: Saturday, September 20th, 12:00 PM EST
Texas Tech and Utah are both on the fringe of making the college football playoff, and this is a game both teams will look back on at the season’s end. It may only be week 4 of the college football season, but this matchup will go a long way in determining their respective postseason futures.
Texas Tech has cruised to three big wins so far this season, with the last two coming by way of 62-14 and 67-7 wins. Utah represents a massive step up in competition, but Texas Tech will be confident that it can defy the college football odds with a crucial road victory. Quarterback Behren Morton has been excellent for the Red Raiders, but he will really boost his potential draft stock with a victory to kick off week 4.
Utah has been dominant as well, including a big win over UCLA last week, but this kind of point spread doesn’t reflect how close this game may be.
Two explosive offenses going head-to-head is sure to deliver fireworks, and we will take the free points with Texas Tech for the first college football week 4 prediction.
Pick: Texas Tech (+3.5) -120
For more expert breakdowns, check out our College Football Week 3 Predictions
(#9) Illinois at (#19) Indiana
- Spread: Illinois +4.5, Indiana -4.5
- Moneyline: Illinois +140, Indiana -210
- Over/Under: 52.5 Points
- Time: Saturday, September 20th, 7:30 PM EST
These two college football rivals square off in week 4, and this is one of the best matchups to make NCAAF predictions with your sportsbook. Illinois may be ranked ten spots higher than Indiana, but it is a moderate underdog on the college football odds. And rightfully so.
Indiana has been playing dominant football this season and has shown no signs of slowing down now. They made it look easy last week with a 73-0 victory over their interstate rivals, allowing just 77 yards on the defensive side of the ball. The Indiana defense is in for a tougher task against Illinois, but this is still certainly their game to lose. Fernando Mendoza will almost certainly be drafted to the NFL and will not let up, regardless of the score.
Another Indiana blowout win is on the cards, and we will happily lay the points on the home team with the college football point spread.
Pick: Indiana -4.5 (-115)
College Football Week 4 Odds FAQ
When do College Football Week 4 games begin?
College football week 4 games kick off on Thursday, September 18th, 2025, at 7:30 PM EST. Rice takes on Charlotte as the lone Thursday night matchup, and the ranked teams don’t play in week 4 until Saturday, September 20th, 2025. Nineteen of the 25 ranked teams play on Saturday this week, with the games kicking off from Noon EST until 11 PM EST for an action-packed day of college football action.
What is the Best Game this Week?
There are three ranked vs. ranked matchups this week, but the best game is 9th-ranked Illinois and 19th-ranked Indiana. These two schools are both confident in their ability to make the college football playoff, but an early-season loss will put them on the outside looking in on the playoff spots.
