There is no shortage of games to choose from for your college football predictions this week, and the NCAAF odds have just been released.
Seven of the top 10 teams are playing this week, with numerous mouthwatering matchups highlighting the slate. Georgia and Alabama always produce memorable matchups, while Penn State and Oregon will battle for the top spot on Saturday, September 27th, 2025.
The stage has been set, your NCAAF predictions are here, so let’s dive right into the college football predictions for week 5.
College Football Week 5 Odds
The NCAAF odds can often be quite wide due to extreme mismatches at the collegiate level, but the college football odds for week 5 feature several close matchups. The top spot in the nation could be on the line, and there are a handful of teams battling it out with their playoff hopes dangling by a thread at this early stage of the season.
Analyzing the American Football odds before making your college football week 5 predictions is crucial for success, and here are the college football odds for week 5 in the major matchups scheduled.
| Matchup | Spread | Moneyline | Over/Under |
| Florida State at Virginia | Florida State -7.5 (-110) | FSU -325/VIR +210 | 57.5 |
| TCU at Arizona State | Arizona State -2.5 (-125) | TCU +100/AS -145 | 54.5 |
| USC at Illinois | USC -6.5 (-135) | USC -275/ILL +180 | 59.5 |
| Notre Dame at Arkansas | Notre Dame -4.5 (-130) | ND -230/ARK +155 | 64.5 |
| Utah State at Vanderbilt | Vanderbilt -22.5 (-120) | Utah State +800 | 59.5 |
| Ohio State at Washington | Ohio State -8.5 (-120) | OS -375/WAS +230 | 52.5 |
| LSU at Ole Miss | Ole Miss -2.5 (-120) | LSU +100/OLE -145 | 55.5 |
| Auburn at Texas A&M | Texas A&M -6.5 (-115) | AUB +180/A&M -275 | 55.5 |
| Indiana at Iowa | Indiana -8.5 (+100) | IND -325/IOW +210 | 48.5 |
| Tennessee at Mississippi State | Tennessee -7.5 (-120) | TEN -350/MIS +220 | 62.5 |
| Arizona at Iowa State | Iowa State -6.5 (-120) | ARZ +180/ISU -275 | 49.5 |
| Oregon at Penn State | Penn State -3.5 (-120) | ORE +130/PENN -190 | 52.5 |
| Alabama at Georgia | Georgia -3.5 (-105) | ALA +120/GEO -175 | 53.5 |
| BYU at Colorado | BYU -6.5 (-120) | BYU -260/COL +170 | 47.5 |
College Football Week 5 Odds Analysis
(#6) Oregon at (#3) Penn State
- Spread: Oregon +3.5, Penn State -3.5
- Moneyline: Oregon +130, Penn State -190
- Over/Under: 52.5 Points
- Time: Saturday, September 27th, 7:30 PM EST
Oregon faces its first real test of the season when it plays Penn State on the road in the featured game of week 5. Penn State is one of the best teams in the nation, but Oregon should not be a big underdog on the college football week 5 odds.
Oregon has made quick work of its recent opposition, with Dante Moore looking better and better every time he takes the field. Moore transferred from UCLA and has slotted into the Oregon offense seamlessly. Dillon Gabriel was a tough man to replace, but Moore has given new life to the Ducks’ offense.
Penn State is tough on defense, but Oregon knows how to win close football games, and we will take them on the moneyline for the top college football week 5 prediction.
Pick: Oregon Moneyline +130
For more expert breakdowns, check out our College Football Week 4 Predictions
(#17) Alabama at (#5) Georgia
- Spread: Alabama +3.5, Georgia -3.5
- Moneyline: Alabama +120, Georgia -175
- Over/Under: 53.5 Points
- Time: Saturday, September 27th, 7:30 PM EST
These SEC rivals have a bitter rivalry that has shown no signs of slowing down now. Alabama was able to shake off its week 1 loss to Florida State and faces their next big test this week when they head to Georgia.
Alabama has struggled to maintain its dominant streak from when Nick Saban was the head coach, but it has an opportunity to defy the college football odds with a big showing in week 5. However, their defense has looked vulnerable against poor offenses, which leads us to take Georgia to win and cover for our college football week 5 predictions.
The Georgia Bulldogs have an experienced quarterback in Gunner Stockton after they took their time developing the young stud. Stockton led the Bulldogs to an overtime victory against Tennessee two weeks ago and will be confident against the Crimson Tide.
Many teams have promising quarterbacks on their roster, but what sets Georgia apart is their offensive depth. Nine players caught a pass in their victory over the Volunteers, with eight players recording a rushing attempt, too.
They have no shortage of weapons to beat down on Alabama and will comfortably win and cover in week 5.
Pick: Georgia -3.5 (-105)
College Football Week 5 Odds FAQ
When do College Football Week 5 games begin?
College football week 5 games begin on Thursday, September 25th, 2025, at 7:30 PM EST. Army heads to Carolina to take on East Carolina in the only game on Thursday night. Unlike most weeks, the scheduling committee has treated fans to not one, but two ranked teams on Friday, September 26th. Virginia hosts #8 Florida State at 7:00 PM EST on Friday, before Arizona State welcomes TCU to town at 9:00 PM EST.
What is the Best Game this Week?
There are four ranked vs ranked matchups this week, and it is difficult to select the best game on this week. #17 Alabama and #5 Georgia have a deeply rooted rivalry that is as intense as ever, but they haven’t been able to produce dominant results on the field in recent years. That leaves #6 Oregon against #3 Penn State to take the title of best game on this week.
