The San Francisco 49ers have lofty expectations heading into the regular season, and this is a great opportunity to fine-tune their roster before the year gets underway.
The NFL odds favor the Las Vegas Raiders to pick up the victory in this preseason affair, but the 49ers have been counted out by free sportsbooks in the past. The Raiders will be eager to get Geno Smith up to speed after his offseason move to Las Vegas, and his level of play will have a serious impact on how the Raiders play, not only in this matchup but also for the upcoming NFL season.
Can the 49ers use their depth to overcome the NFL odds on Saturday, or will the Raiders remain undefeated in the preseason and send the home fans home happy?
Matchup: 49ers vs Raiders Overview
- Teams: San Francisco 49ers at Las Vegas Raiders
- Date: Saturday, August 16th, 2025
- Time: Kick-off is at 4:00 PM EST
- Venue: Allegiant Stadium in Paradise, Nevada
Current 49ers vs Raiders Odds
| San Francisco 49ers | Las Vegas Raiders | |
| Moneyline | +155 | -230 |
| Total | Over 40.5 Points (-120) | Under 40.5 Points (-120) |
The NFL odds favor the Las Vegas Raiders to defend their home field against the San Francisco 49ers this weekend.
It is not surprising to see these kinds of American football odds for your 49ers vs Raiders prediction, given how San Francisco played in their first preseason game. This team is already riddled with injuries heading into the season, so they have been openly experimenting with players deep in their depth chart throughout preseason play.
Meanwhile, the Las Vegas Raiders tied their first preseason game, and have the advantage of playing at home for this one. Geno Smith will be their Week 1 starter, but even Aidan O’Connell is capable of putting up points for the Raiders. The NFL odds for the total points are quite high for a preseason tilt at 40.5 points.
Expert Prediction: Who Wins?
Why the San Francisco 49ers Can Win
The San Francisco 49ers were competing for the Super Bowl just a few seasons ago, and will want to build their depth throughout the preseason. There are still question marks surrounding both the health and skillset of Quarterback Brock Purdy, but the 49ers have a solid backup in Mac Jones.
Jones will likely be called on for long stretches of this matchup, and he can pick apart the Raiders’ defense. Las Vegas has been mixing things up defensively, and if they elect to rest their starters once again, this will be the 49ers’ game to lose.
Understandably, Kyle Shanahan has been hesitant to play his starters in the preseason, given the 49ers’ recent injury woes. Christian McCaffrey and Brandon Aiyuk have been unable to stay on the field, and Shanahan does not want to risk their health for a relatively meaningless game.
However, the 49ers have Super Bowl experience up and down their roster, while the Raiders haven’t won a playoff game in more than two decades. That fact alone will tilt the NFL odds in favor of the 49ers, and if they end up playing some of their starters in the first half, they are a great underdog for your 49ers vs Raiders predictions.
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Why the Las Vegas Raiders Can Win
The best ability is availability, and the Raiders have a serious advantage in that category over the 49ers.
The injuries up and down the 49ers roster cost them their season last year, and they still haven’t gotten healthy heading into this preseason game. If everyone were healthy and playing, the 49ers would certainly be the favorites on the NFL odds. However, that is not the case, and the Raiders will look to take advantage of the personnel the 49ers are forced to roll with for this one.
Geno Smith was virtually a spectator in the Raiders’ first preseason game, but he will have an increased role in their upcoming matchup against the 49ers. Smith will be looking to take control of this offense during his first season in Las Vegas, and this is the perfect opportunity to warm up for the regular season.
He is unlikely to play all four quarters, but he will get in his reps and be able to build a lead for the home team. If the Raiders bring the same intensity into this matchup as they did in their first preseason game against the Seahawks, they will prove to be an excellent Raiders vs 49ers prediction.
However, the NFL odds are steeply in their favor, so waiting to make an NFL pick against the spread could be the wiser move for Saturday afternoon.
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