The NFL season is into the final three weeks, and there is still plenty to play for as the regular season wraps up. Only two teams have clinched a playoff spot, with a total of 17 teams fighting for the final 12 playoff spots. The NFL odds have been released for all 16 games in week 16, with some tantalizing matchups penciled in for this weekend. Be sure to analyze the top expert NFL picks for this week before you head to your sportsbook to make NFL week 16 predictions.
NFL Week 16 Predictions and Picks
Game 1: Green Bay Packers at Chicago Bears
Saturday, December 20th, 8:20 PM EST
- Moneyline: Packers -120, Bears -115
- Spread: Green Bay Packers (-1.5)
- Total: 46.5 Points
The NFC North is on the line in this one, as the Packers and Bears fight for the division lead. Green Bay got the best of Chicago when they met at Lambeau Field two weeks ago, but this meeting will be very different in Chicago. The NFL odds have made the Packers slight road favorites, but the wrong team is favored in this matchup.
Chicago has the better and healthier defense, Caleb Williams has looked great on offense, making this their game to lose. The Packers’ offensive issues have been masked by stellar defensive play, but that will no longer suffice with Micah Parsons injured for the remainder of the season.
Pick: Chicago Bears Moneyline -115
Game 2: Tampa Bay Buccaneers at Carolina Panthers
Sunday, December 21st, 1:00 PM EST
- Moneyline: Buccaneers -175, Panthers +125
- Spread: Tampa Bay Buccaneers (-2.5)
- Total: 45.5 Points
Neither of these teams could take advantage of an easy matchup last week, and now face off for their first of two meetings in the final three weeks of the year. The Buccaneers have started to get healthy with Mike Evans and Tristan Wirfs bolstering their offense, but they still shouldn’t be road favorites in this divisional matchup.
The Panthers’ run game is among the best in the league, and they will look to drain the clock and keep the ball out of Baker Mayfield’s hands. The plus money NFL odds on the point spread make the Panthers a great value pick at home.
Pick: Carolina Panthers (+2.5) +100
Game 3: New York Jets at New Orleans Saints
Sunday, December 21st, 1:00 PM EST
- Moneyline: Jets +175, Saints -250
- Spread: New Orleans Saints (-4.5)
- Total: 40.5 Points
Both of these teams are already scouting the 2026 NFL Draft, but there is still football to be played in Louisiana. The Jets used to be a strong defensive unit, but after selling at the trade deadline, they haven’t been able to get stops.
For the Saints, Tyler Shough has been rolling on offense, but it isn’t time to pretend this is a strong defensive unit. Both of these teams are where they are in the standings thanks to poor play on defense, as they actually have a pair of undervalued offenses. With the total points at 40.5 on the live sports odds, the over is the way to go.
Pick: Over 40.5 Points (-120)
NFL Player Prop Predictions: Los Angeles Rams at Seattle Seahawks
Thursday, December 18th, 8:15 PM EST
- Moneyline: Rams -115, Seahawks -120
- Spread: Seattle Seahawks (-1.5)
- Total: 42.5 Points
Kyren Williams has been a machine on the ground this season, and the +110 NFL odds are the best player prop for Thursday night. Blake Corum has found the end zone four times in the last three games, which has led the public to believe Williams’ time in the Rams backfield is coming to an end. However, that is not the case. Williams has scored in three straight games and six of his last seven for Los Angeles. At +110, these are fantastic NFL odds.
Pick: Kyren Williams Touchdown +110
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NFL Score Predictions: Philadelphia Eagles at Washington Commanders
Saturday, December 20th, 5:00 PM EST
- Moneyline: Eagles -325, Commanders +215
- Spread: Philadelphia Eagles (-6.5)
- Total: 44.5 Points
The Washington Commanders don’t do much right, but they are happy to take kickoffs out of the end zone. The Eagles will be doing lots of scoring in this matchup, which will give Jaylin Lane several opportunities to run one back to the house. Once you add in the fact that Marcus Mariota is an interception machine, these are great NFL odds for either team to score a non-offensive touchdown.
Pick: Defensive or Special Teams Touchdown? Yes +240
NFL Moneyline Predictions: San Francisco 49ers at Indianapolis Colts
Monday, December 22nd, 8:15 PM EST
- Moneyline: 49ers -320, Colts +215
- Spread: San Francisco 49ers (-5.5)
- Total: 46.5 Points
The Colts will be marching out 44-year-old Philip Rivers for this matchup. He takes on a hungry 49ers defense with real playoff aspirations, and it is hard to imagine the Colts pulling off a road upset. San Francisco is simply too good on both sides of the ball to lose this one, making them the perfect parlay piece of a safe moneyline pick.
Pick: San Francisco 49ers Moneyline -320
NFL Against the Spread Predictions: Jacksonville Jaguars at Denver Broncos
Sunday, December 21st, 4:05 PM EST
- Moneyline: Jaguars +135, Broncos -190
- Spread: Denver Broncos (-3.5)
- Total: 46.5 Points
The Denver Broncos have won 11 games in a row, but they haven’t all been blowouts. Six of their last nine wins have come by three points or fewer, making a line above a field goal hard to justify. The Jaguars are on a hot streak of their own; they have a truly lethal offense, and the Broncos will struggle to pull away. Even with the NFL odds at -140, the Jaguars are the way to go for your against the spread week 16 NFL predictions.
Pick: Jacksonville Jaguars (+3.5) -140
