There are two games left in the NFL season, and the fate of the Super Bowl contenders will be decided in the next 14 days. Some teams will have their dreams shattered in the final weeks, while others will book their spot in the playoffs with crucial victories.
Before making your NFL week 17 predictions, make sure you carefully analyze the NFL odds on your sportsbook and read over the expert NFL week 17 predictions provided below. By doing so, you can maximize your chances of beating the football odds with correct NFL week 17 predictions.
NFL Week 17 Predictions and Picks
Game 1: Dallas Cowboys at Washington Commanders

Thursday, December 25th, 1:00 PM EST
- Moneyline: Cowboys -320, Commanders +215
- Spread: Dallas Cowboys (-6.5)
- Total: 50.5 Points
Both of these teams have had disappointing seasons, and this total is too high for these NFC East rivals. Dallas is known for their electric offense, but it has looked mundane in recent weeks, and the Washington defense has shown signs of life.
On the other side of the ball, the Commanders are down to their third-string quarterback, Josh Johnson, who is one of the worst players in the league.
The live sports odds are far too high for these two disjointed franchises, making the under a great NFL Week 17 prediction.
Pick: Cowboys vs Commanders Under 50.5
Game 2: Seattle Seahawks at Carolina Panthers

Sunday, December 28th, 1:00 PM EST
- Moneyline: Seahawks -400, Panthers +260
- Spread: Seattle Seahawks (-7.5)
- Total: 42.5 Points
The Carolina Panthers continue to defy expectations with inspired play on both sides of the ball. Their consistent run game and hard-nosed defense make them a hard team to bully, and this is way too many points for them at home.
Bryce Young and the Panthers have been written off in the past, but it is their time to win the NFC South, and they will not roll over easily.
This is a big game for both franchises, and one that should go right down to the wire. The +260 moneyline is certainly tempting, but with the spread at a key number, we will take the points instead for the week 17 NFL prediction.
Pick: Carolina Panthers (+7.5)
Game 3: Pittsburgh Steelers at Cleveland Browns

Sunday, December 28th, 1:00 PM EST
- Moneyline: Steelers -250, Browns +175
- Spread: Pittsburgh Steelers (-4.5)
- Total: 34.5 Points
This is a rock bottom total for this matchup. Even though both of these teams are known for their work on the defensive side of the ball, the NFL odds of -120 on over 34.5 points aren’t an opportunity that comes around very often.
The Browns’ offense is led by Shedeur Sanders, whose erratic play can lead to points on the board for both teams. This is a must-win game for the Steelers if they hope to clinch the AFC North before week 18, and they will keep piling on the points if they build a big lead.
Taking an over in a Browns-Steelers game is never fun, but with these NFL odds, it is the only choice.
Pick: Steelers vs Browns Over 34.5
NFL Player Prop Predictions: Detroit Lions at Minnesota Vikings
Thursday, December 25th, 4:30 PM EST
- Moneyline: Lions -290, Vikings +195
- Spread: Detroit Lions (-6.5)
- Total: 44.5 Points
All the attention is on Jahmyr Gibbs in the backfield, but his -200 touchdown odds are unplayable.
Instead, the best player prop prediction to make is on David Montgomery to find the endzone. Montgomery and Gibbs see a relatively even split in the backfield, with Montgomery getting his fair share of red zone touches.
This is a game where the Lions are heavily favored in many NFL predictions, and they will be running the football early and often.
Pick: David Montgomery Touchdown +110
NFL Score Predictions: New England Patriots at New York Jets
Sunday, December 28th, 1:00 PM EST
- Moneyline: Patriots -1200, New York Jets +525
- Spread: New England Patriots (-13.5)
- Total: 44.5 Points
We need to play the -250 NFL odds in week 17. The odds could be longer, but for a highly likely prop, we will still take it.
New England can get one step closer to clinching the AFC East with a win, while the Jets are having a terrible season since their first and second-string quarterbacks got hurt.
Not much to like about New York right now, as the Pats will get off to a hot start.
Pick: First team to score, New England Patriots -250
NFL Moneyline Predictions: Houston Texans at Los Angeles Chargers
Saturday, December 27th, 4:30 PM EST
- Moneyline: Texans -105, Chargers -130
- Spread: Los Angeles Chargers (-2.5)
- Total: 39.5 Points
This is a great price on the Chargers’ moneyline. Houston is the hottest team in the league, but they haven’t been as dominant on the road in recent weeks. Los Angeles’s offensive line issues will be offset by inspiring defensive play, and home-field advantage will come into play during a field-position battle.
CJ Stroud still has to prove himself in the pocket for Houston, and -130 moneyline odds for the home team are too good to pass up.
Pick: Los Angeles Chargers Moneyline -130

NFL Against the Spread Predictions: Philadelphia Eagles at Buffalo Bills
Sunday, December 28th, 4:05 PM EST
- Moneyline: Eagles +110, Bills -155
- Spread: Buffalo Bills (-2.5)
- Total: 43.5 Points
The Eagles have already clinched the NFC East, but are still battling for playoff seeding in the NFC. Their physical play has dominated Buffalo in the past, and this is a great spot to do so again on Sunday afternoon.
The Bills have postseason aspirations of their own, but we will take any points we can get in a matchup between two Super Bowl contenders.
Pick: Philadelphia Eagles (+2.5) -120
ALSO CHECK OUT: NFL Week 16 Predictions





