The NFC North is still up for grabs, and the winner of this game will likely go on to win the division. Both the Packers and Lions have gotten off to strong starts this season, and a competitive NFC North with the 7-3 Bears leading the way makes this a highly competitive matchup.
The NFL odds give a slight edge to the home team, but both sides will be confident that they are the right NFL prediction to make. The Philadelphia Eagles cooled down Detroit’s electric offense, and the Packers’ defense will look to make a similar impact in this matchup.
However, Green Bay’s offense has faltered, and it won’t take many points from the Lions to prevail.
Only one of these Super Bowl contenders can emerge with a win, so let’s get right into your Lions vs Packers predictions for Thursday Night Football.
Matchup: Lions vs Packers Overview
- Teams: Green Bay Packers at Detroit Lions
- Date: Thursday, November 27th, 2025
- Time: Kickoff is at 8:15 PM EST
- Venue: Ford Field in Detroit, Michigan
Current Lions vs Packers Odds:
| Detroit Lions | Green Bay Packers | |
| Moneyline | -150 | +120 |
| Spread | +2.5 (-120) | -2.5 (-120) |
| Total | Over 48.5 Points (-120) | Under 48.5 Points (-120) |
The NFL odds give the Detroit Lions a slight edge, mainly due to home-field advantage.
The Lions are 3-1 at home this season, and a crucial win over the Packers would put them in pole position to win the NFC North. However, Green Bay has defied the American Football odds before, and they will be confident they can pull off an upset.
For the over/under, a line of 48.5 has been set. Both of these teams stayed under that total in Week 11, making the under a tempting NFL prediction for this matchup.
Why the Detroit Lions Can Cover
The Detroit Lions will have revenge on their mind after losing to the Packers earlier this season, and their NFC North hopes hinge on taking care of business in this matchup.
Detroit has been excellent at home this season, and with a point spread under 3 points, almost all their wins will also result in a cover, making them a popular NFL prediction in this spot.
On offense, the Lions have endless options on how to hurt their opponents. On the ground, David Montgomery and Jahmyr Gibbs have been one of the most effective one-two punches in the league. Through the air, both Jameson Williams and Amon-Ra St. Brown could be WR1s on many teams in the league.
To cap it off, they have a responsible Jared Goff in the pocket, the reliable Sam LaPorta at tight end, and an excellent playcaller in Dan Campbell. The Lions will look to get their offense going after going 0-for-5 on fourth-down attempts against the Eagles in Week 11, and this is the perfect opportunity to do so in a divisional matchup.
If the Lions’ defense can frustrate Jordan Love and the Packers’ offense, this will be their game to lose. The NFL odds favor them to take care of business at home, and they are an excellent prediction to cover the spread. Fewer than 5% of NFL games finish with a winning margin of 2 points or less, making the NFL point spread odds the way to go over the moneyline.
Why the Green Bay Packers Can Cover
The Green Bay Packers have the benefit of a few points on the point spread, and their aspirations in this matchup will come down to how their offense can perform.
Jordan Love has looked lost in the pocket for Green Bay, as he has really struggled to find consistency from week to week. One week, the Packers are dropping 40 points on the Cowboys, and the next, they are being held to single digits on primetime.
The knee injury to Josh Jacobs will hurt their run game even more, which means Love must step up if the Packers are to cover the spread.
On defense, Green Bay has been excellent. They are top ten in passing yards allowed, rushing yards allowed, and points allowed this season. Their ability to neutralize opponents’ greatest weapons has enabled them to excel when the offense is underperforming.
The Lions frequently get creative in how they break down strong defenses, and Green Bay has the tools it needs to shut down Dan Campbell’s offense. It is a bit surprising to see the Packers as playable underdogs on the NFL odds, as they already beat the Lions 27-13 earlier this season in a very one-sided affair.
With these kinds of football odds, a Packers vs Lions prediction on the Green Bay Packers to not only cover the spread, but win outright could be a fruitful proposition.
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How to Make Detroit Lions vs Green Bay Packers Picks
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Whether you expect the Lions to defend Ford Field with a crucial win or you think the Packers can pull off the upset, Sportzino is the perfect place to make all your NFL predictions this season.
