Saints vs Chargers Prediction

The New Orleans Saints are expected to be one of, if not the worst, team in the NFL this season, but they may be able to find some success in the preseason. Justin Herbert and the rest of the Chargers’ starters are unlikely to play in this game, and if they do, their appearance will be brief. Instead, Taylor Heinicke and Trey Lance will split the reps for Los Angeles, which is reflected in the NFL odds. Even though this game will have no implications on the standings, you can still make NFL predictions using your free sportsbook. New Orleans has plenty of kinks to work out all over the field, and whoever gets the nod at quarterback will be looking to solidify their role in that position. Can Spencer Rattler, Tyler Shough, or Jake Haener impact this game, or will the Chargers make it a perfect 2-0 to kick off their preseason campaign? 

Matchup: Saints vs Chargers Overview

• Teams: New Orleans Saints at Los Angeles Chargers
• Date: Sunday, August 10th, 2025
• Time: Kick-off is at 4:05 PM EST
• Venue: SoFi Stadium in Inglewood, California

Current Saints vs Chargers Odds

The NFL odds for the Saints vs Chargers preseason matchup are very close, with the New Orleans Saints getting the slight nod with -125 odds to win. The preseason may not have any tangible awards to play for, but the ability to use a free sportsbook to make Saints vs Chargers predictions makes this an unmissable matchup. The American football odds are very close despite the Chargers’ early preseason success, and this appears to be a tight matchup in California this weekend. The NFL odds for the total points are much lower than in the regular season, as 36.5 would be one of the lowest totals of all time in the regular season. Instead, this is expected to be a high-scoring preseason game, as most preseason NFL football matchups have a total in the low 30s. 

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Expert Prediction: Who Wins? 

Why the New Orleans Saints Can Win

The New Orleans Saints have a multitude of average players on their roster, and every single player on the field will be fighting for a potential roster spot in September. The extra intensity from not only the quarterback but from every player on the field will give the Saints a serious advantage. This must be a factor when considering your Saints vs Chargers predictions, as motivation is everything when it comes to making NFL picks in the preseason. 

The Saints are in an unfortunate position this season as they don’t have a solidified starting quarterback. Rattler, Shough, and Haener all have the chance to snatch the starting role, and they are being listed as ‘joint QB1s’ on the depth chart. All three have their strengths and weaknesses, and will likely split the snaps in this matchup. Regardless of who plays, the extra intensity will give the Saints an edge and make them a worthy NFL prediction for this preseason affair. 

Motivation is everything in the preseason, and the fact that the Chargers already got their first win out of the way could see them take their foot off the gas in this matchup. If the Saints elect to play their expected starters for long stretches, which is a real possibility, this will be their game to lose. Predicting what portion of the game the starters will play is crucial for your Chargers vs Saints predictions. 

Why the Los Angeles Chargers Can Win

The Los Angeles Chargers got dealt terrible injury news that Rashawn Slater will miss the entire season, but he was unlikely to suit up for this game anyway. While that will certainly hurt the morale in the locker room, Los Angeles still has a very competitive squad that already has a preseason game in the rearview mirror this season. Trey Lance dominated the Hall of Fame Game to kick off the preseason, and the Chargers will feel confident they can do so again when they match up against the Saints. 

Los Angeles has been a competitive team that has been unable to get over the hump in the AFC over the last half-decade. Justin Herbert may play for the first drive or two, and even that may be enough to shift the NFL odds in favor of the Chargers. Herbert is miles better than anyone on the Saints roster, and an early 14-0 lead will be too much for New Orleans’ trio of quarterbacks to overcome. This is a team that has tweaked its receiving room quite heavily in the offseason, and building a connection with Herbert in a game-like situation will be crucial to their success. 

How to Make New Orleans Saints vs Los Angeles Chargers Picks

When it comes to making your New Orleans Saints vs Los Angeles Chargers picks, there’s no better place to turn than Sportzino. You get non-stop access to incredible NFL odds all preseason long, and Sportzino is the ultimate destination to start the new NFL season off right. Whether you’re into player props, spreads, totals, or moneylines, Sportzino has all the American football odds you desire. Best of all, Sportzino provides free NFL picks and predictions for every preseason NFL game, making it the clear choice for all Saints vs Chargers predictions.