The NFL season has officially ticked into the second half, as time is running out for the contenders to secure their spot in the postseason. There has never been a better time to make your NFL week 10 predictions on Sportzino. Once you visit Sportzino, you will be able to make expert picks and predictions to help you make your own free 2024 NFL week 10 predictions. Make sure you carefully examine all the available NFL week 10 odds before making your NFL week 10 predictions.

Expert NFL Week 10 Predictions on the Best 5 Games
Game 1: New York Giants vs Carolina Panthers
Sunday, November 10th, 9:30 AM EST
- Moneyline: Giants -240, Panthers +180
- Spread: New York Giants (-5)
- Total: 41.5 Points
The NFL heads back to Europe for this matchup between two struggling franchises. While the talent may not be there, the NFL odds available on the Carolina Panthers moneyline make them a fantastic NFL week 10 prediction. The Panthers are coming off a big win against the Saints in week 9, while the Giants have lost four consecutive games. Panthers quarterback Bryce Young has begun to show signs of improvement, and the +180 odds on the Panthers to win this NFL matchup
Pick: Carolina Panthers Moneyline +180
Game 2: Buffalo Bills at Indianapolis Colts
Sunday, November 10th, 1:00 PM EST
- Moneyline: Bills -210, Colts +160
- Spread: Buffalo Bills (-4)
- Total: 46 Points
The Bills have virtually locked up the AFC East with a healthy four-game lead over the 3-6 Jets, but they still have plenty of motivation to secure the top spot in the AFC. Josh Allen has been playing superhuman football, and the Colts are alternating between Anthony Richardson and Joe Flacco at quarterback. Buffalo is the more consistent team, and this is a short spread for your NFL Week 10 predictions.
Pick: Buffalo Bills (-4) -110

Game 3: San Francisco 49ers at Tampa Bay Buccaneers
Sunday, November 10th, 1:00 PM EST
- Moneyline: 49ers -240, Buccaneers +180
- Spread: San Francisco 49ers (-5.5)
- Total: 51 Points
The Buccaneers offense has been able to make up for their defense’s shortcomings all season long. The 49ers are not the offensive force they once were due to injuries, and it’s hard to see them winning by a touchdown on the road against Tampa Bay. Buccaneers quarterback Baker Mayfield has thrown for 15 touchdowns in his last five games, and he will generate enough offense against the 49ers to get the cover at home.
Pick: Tampa Bay Buccaneers (+5.5)
Game 4: Pittsburgh Steelers at Washington Commanders
Sunday, November 10th, 1:00 PM EST
- Moneyline: Steelers +125, Commanders -160
- Spread: Washington Commanders (-3)
- Total: 45.5 Points
Both of these teams have exceeded expectations this year, but only one of them can keep the momentum alive this week. The Commanders just acquired star corner Marshon Lattimore to shore up their defense, and that will be the difference maker against a strong Steelers defense. Quarterback Jayden Daniels just keeps getting better for Washington, and the Steelers will struggle to match the Commanders’ offensive output. Pittsburgh rarely gets blown out, so the moneyline is the safer NFL week 10 prediction rather than the spread.
Pick: Washington Commanders Moneyline -160
Game 5: Detroit Lions at Houston Texans
Sunday, November 10th, 8:20 PM EST
- Moneyline: Lions -190, Texans +145
- Spread: Detroit Lions (-3.5)
- Total: 49.5 Points
This could have been a great NFL week 10 matchup, but the injuries to the Texans’ offense will allow the Lions to make it look easy in Houston. Texans quarterback CJ Stroud has been consistent this season, but without wide receivers Nico Collins and Stefon Diggs, he has struggled. Detroit has been ruthless on offense this year, and they will have no problem piling on the points against the Texans on Sunday night.
Pick: Detroit Lions (-3.5) -110

NFL Week 9 Expert Predictions
NFL Player Prop Predictions: Cincinnati Bengals at Baltimore Ravens
Thursday, November 7th, 8:0150 PM EST
- Moneyline: Bengals +205, Ravens -275
- Spread: Baltimore Ravens (-6)
- Total: 52.5 Points
The Ravens’ offense, led by Derrick Henry and Lamar Jackson, has stolen the spotlight, but Zay Flowers’s efficiency can no longer be ignored. He found the endzone twice against the Broncos last week and will do so again on Thursday against the Bengals. The Cincinnati defense has been abysmal this year through the air, and there is no reason to think Jackson and Flowers can’t link up for your NFL week 10 predictions for Thursday Night Football.
Pick: Zay Flowers Touchdown +180
NFL Score Predictions: Dallas Cowboys at Philadelphia Eagles
Sunday, November 10th, 4:25 PM EST
- Moneyline: Cowboys +275, Eagles -375
- Spread: Philadelphia Eagles (-7)
- Total: 43 Points
These defenses are both more consistent than their respective offensive units, and they will have difficulties finding the endzone consistently. Dallas quarterback Dak Prescott is injured for this matchup, meaning Cooper Rush and Trey Lance will split the starting role. On defense, the Cowboys will prioritize shutting down Saquon Barkley’s run game. This total is too high, which allows the under to be a nice 2024 NFL week 10 prediction.
Pick: Total Touchdowns Under 4.5 -105
NFL Moneyline Predictions: Miami Dolphins at Los Angeles Rams
Monday, November 11th, 8:15 PM EST
- Moneyline: Dolphins +110, Rams -140
- Spread: Los Angeles Rams (-2.5)
- Total: 51 Points
The return of Dolphins quarterback Tua Tagovailoa has not solved Miami’s offensive struggles. Tyreek Hill hasn’t been as effective as in recent seasons, and he will struggle to get going on the road against the Rams. Los Angeles quarterback Matthew Stafford is one of the most consistent performers in the league, and he will make sure his team edges out a victory on Monday night.
Pick: Los Angeles Rams Moneyline -140
NFL Against the Spread Predictions: New England Patriots at Chicago Bears
Sunday, November 10th, 1:00 PM EST
- Moneyline: Patriots +205, Bears -275
- Spread: Chicago Bears (-6)
- Total: 39.5 Points
The Chicago Bears are quickly falling out of the race for the NFC North divisional crown, and this is absolutely a must-win game for them this weekend. The Patriots’ offense has struggled all season, and their defense has suddenly started to fail them too. Chicago is built well on both sides of the ball and has been unlucky in their recent defeats. For your final NFL week 10 prediction, take the Bears to easily cover the spread in a dominant home victory.
Pick: Chicago Bears (-6) -105





