A fantastic weekend across the nation in college football action came to a close on Saturday night, with a wild stretch of games topped off by No. 1 Oregon avoiding defeat after a scare from the Wisconsin Badgers in Madison.
Now, it’s time to turn the page to Week 13 and look at the college football odds for the slate ahead this weekend. With the penultimate week of the regular season here, so much hinges on the next couple of weeks of play around the country.
With bowl games and, of course, the College Football Playoff picture to be decided, it’s time to look at this week’s NCAA football odds before it’s time for college football predictions.
College Football Week 13 Odds
| Matchup | Spread | Moneyline | Over/Under |
| Purdue at Michigan State | Michigan State -13.5 (-120) | Purdue +375/Michigan State -750 | 48.0 |
| North Carolina at Boston College | North Carolina -3 (-125) | North Carolina -175/Boston College +120 | 56.5 |
| Mississippi at Florida | Mississippi -10 (-120) | Mississippi -475/Florida +275 | 55.5 |
| Iowa at Maryland | Iowa -6.5 (-120) | Iowa -290/Maryland +190 | 46.5 |
| Indiana at Ohio State | Ohio State -13 (-120) | Indiana +330/Ohio State -600 | 52.0 |
| Illinois at Rutgers | Rutgers -1 (-120) | Illinois -115/Rutgers -125 | 48.0 |
| UMass at Georgia | Georgia -42 (-125) | UMass +1000/Georgia OTB | 55.5 |
| Western Kentucky at Liberty | Western Kentucky -1 (-120) | Western Kentucky -125/Liberty -115 | 57.0 |
| Arizona at TCU | TCU -11.5 (-120) | Arizona +285/TCU -500 | 59.0 |
| Stanford at Cal | Cal -14 (-120) | Stanford +375/Cal -750 | 55.0 |
| Colorado at Kansas | Colorado -2.5 (-125) | Colorado -150/Kansas +105 | 59.5 |
| Wisconsin at Nebraska | Nebraska -2.5 (-120) | Wisconsin +100/Nebraska -145 | 42.5 |
| Kentucky at Texas | Texas -20.5 (-125) | Kentucky +625/Texas -2000 | 47.0 |
| Army at Notre Dame | Notre Dame -14.5 (-115) | Army +425/Notre Dame -900 | 44.5 |
| Washington State at Oregon State | Washington State -13.5 (-120) | Washington State -600/Oregon State +330 | 56.5 |
| Alabama at Oklahoma | Alabama -14 (-120) | Alabama -800/Oklahoma +400 | 47.5 |
| USC at UCLA | USC -5 (-120) | USC -210/UCLA +140 | 51.5 |
College Football Week 13 Odds Analysis
(No. 5) Indiana at (No. 2) Ohio State
- Spread: Ohio State -13 (-120)
- Moneyline: Indiana +330/Ohio State -600
- Over/Under: 52.0
- Time: Saturday, November 23 at 12:00 p.m. ET
It doesn’t get any better than this: Two weeks left in the regular season, and two top-five teams in the nation squaring off. The Hoosiers continued their incredible season with a tight win over Michigan, remaining undefeated and heading into Columbus, and a massive game with Ohio State at 10-0.
The Buckeyes, for their part, will enter the weekend at 9-1, with their sole loss coming to No. 1-ranked Oregon. That, in essence, boils down to why Ohio State is such a sizable favorite here. It’s endured a much more difficult schedule and come out looking strong, with that one-point loss to the Ducks and a win over Penn State the most impressive moments.
Looking for more expert picks? Check out our full College football predictions week 12 breakdown
Between home-field advantage, a superior roster, big-game experience, and their schedule thus far, the Buckeyes should absolutely take a massive win at the Horseshoe. It is, however, a disservice to the Hoosiers to give Ohio State a nearly two-score edge.
Indiana hasn’t simply taken advantage of a soft schedule to get to this point undefeated. The Hoosiers have made a habit of beating up on bad teams, which is, ultimately, all they can do to prove their quality in the spots they’ve been given. With an average margin of victory of 25.5 this season, Indiana may suffer its first loss, but it’ll keep things tight against the Buckeyes.
Pick: Indiana +13 (-120)
(No. 17) Colorado at (NR) Kansas
- Spread: Colorado -2.5 (-125)
- Moneyline: Colorado -150/Kansas +105
- Over/Under: 59.5
- Time: Saturday, November 23 at 3:30 p.m. ET
With a tight win over then No. 6-ranked BYU on the weekend, Kansas kept slight bowl hopes alive and continued to salvage its season after a five-game losing skid early in the year. The Jayhawks have put together a pair of legitimately impressive wins in the last two weeks ahead of welcoming Deion and the Buffs to Kansas City.
That small slice of momentum won’t be enough against a Colorado team that, like it or not, is simply rolling right now. The Buffs have won four straight, all of which came by multiple possessions, and seemingly have leveled up to find an ability that matches the confidence they enter each game with.
The Jayhawks’ win over Big 12-leading BYU led to the 4-6 squad getting a slight push in this line, and it’s to our benefit. Not only have the Buffs proven to be a legitimately reliable, well-performing team this year, but they have consistently beaten inferior opponents with relative ease. That will continue on Saturday.
Pick: Colorado -2.5 (-125)
College Football Week 13 Odds FAQ
When do the College Football Week 13 games begin?
The first college football game of Week 13 is on Tuesday, November 19, at 7:00 p.m. ET, with Akron heading to Kent State. The usual MACtion occurs midweek to kick us off. Friday night features an intriguing matchup in East Lansing between Purdue and Michigan State at 8:00 p.m. ET before the Saturday slate gets underway with a fantastic clash between Indiana and Ohio State at 12:00 p.m. ET.
What is the Best Game on this week?
It’s an exciting slate of matchups in Week 13, but one matchup stands out above the rest, and it’s the one in Columbus. The surprise of the season, the No. 5 Indiana Hoosiers, put their incredible season on the line against Ryan Day’s Ohio State, ranked second in the nation, on Saturday afternoon.
How to Make College Football Week 13 Picks
Ready to make picks on the college football Week 13 slate this weekend? Make sure to head over to Sportzino, where you can find every college football game on the schedule this week and so much more!
