NFL Preseason Predictions

Discover expert predictions for the 2025 NFL preseason! 🏈 Get insights on key matchups, emerging players, and teams to watch as they gear up for the new season.

The NFL preseason picks and predictions are here. The regular season doesn’t kick off for a few more weeks, but there is now the opportunity to make your free preseason NFL predictions while the teams get ready for the season. Preseason NFL football predictions can be more challenging than in the regular season, as teams will almost always rest their starters in favor of giving their practice squad players time on the field. In order to make your free NFL preseason picks, you will need to visit Sportzino.com. Sportzino has numerous preseason NFL odds and lines for the upcoming games. This includes moneyline odds, spreads, and NFL preseason picks for totals and winning margins. It’s time to dive into our expert preseason NFL football predictions for the upcoming week of games. 

What is Pre-Season Football?

Pre-season football is a way for NFL teams to get a few practice games to hit the ground running once the regular season begins. Every NFL team plays at least three games prior to the regular season, but the players on the field will not reflect the opening day squad. When making your NFL preseason predictions, carefully considering the coaches and their playing style has never been more important. Wins and losses don’t matter, but rather the development of their players, and evaluations before crucial roster cuts in the coming weeks. Teams need to use these games to evaluate their talent and sign players for their practice squad. Some starters will play in the preseason, but they will usually only play for a drive or two before sitting down for the backups. 

AFC Preseason Predictions

The preseason picks and predictions for the AFC are always a good set of games to keep an eye on. There are a total of three AFC vs. AFC games in pre-week 1, and they are fantastic candidates for making your free NFL preseason picks. 

The first AFC preseason prediction to make is in the Texans vs. Steelers game on Friday, August 9th. The Steelers are coming in as slight underdogs, but considering the battle for the quarterback position in their dressing room, there will be no shortage of star talent in this game. Justin Fields and Russell Wilson will compete for the starting job and should be heavily featured in this matchup. The Steelers are underdogs, but their superior signal calling will see them outplay Davis Mills and Case Keenum. This makes them an excellent selection for your NFL preseason predictions. 

The next preseason NFL football prediction is in the Chiefs vs Jaguars matchup. The Kansas City Chiefs will march Patrick Mahomes out for one drive maximum, and otherwise, the MVP will be sitting on the bench cheering on his teammates. Despite Patrick Mahomes’ absence, the Jaguars will still be playing with an extra pep in their step against the Chiefs. The reigning Super Bowl champions always bring out the best in their opponents, and at -138 odds, a Jaguars victory is a good NFL preseason prediction. 

NFC Preseason Predictions

There are three all-NFC week 1 matchups, loaded with chances to make your preseason picks NFL. 

The first NFC preseason matchup is between the Dallas Cowboys and Los Angeles Rams. The Cowboys are a well-rounded NFL preseason prediction to make, as they have an edge over the Rams on both sides of the ball. Dak Prescott may make a surprise appearance, as he will be eager to earn the trust of the Cowboys’ front office heading into his contract season. Meanwhile, the Rams have consistently struggled against NFC opponents, and their matchup against Dallas will be no different. The -240 odds on a Cowboys victory is a hefty line, making the spread a better preseason NFL prediction to make. At a -4 line, the Dallas Cowboys are the way to go in this matchup. 

The matchup between the Saints and Cardinals feature two teams desperate to get back into playoff contention. Neither team has been successful in the regular season this decade, and a win, even before the regular season, will mean plenty to these fanbases. The Saints have the depth at quarterback to challenge them here, and Tayson Hill will get some reps as a passer. The Saints are well aware of his impact on the ground, and when they use him in the passing game, he will dominate the Cardinals defenders. The Saints winning and covering the spread is a good NFL preseason pick and prediction to make.