The Indianapolis Colts are sizable home favorites on the NFL odds over the Green Bay Packers, and that goes to show just how unpredictable preseason NFL football can be.
The Packers will not be playing Jordan Love in this matchup, but it is still a valuable opportunity for Green Bay to fine-tune the rest of its roster. The Packers are capable of making a deep run in the NFL playoffs, while the Colts are still looking to qualify for the first time since 2020.
Anthony Richardson appears to be the quarterback of the future for the Colts, but his nagging injuries have forced Indianapolis to acquire Daniel Jones as an insurance policy. This has all the makings of a fun, back-and-forth game in Indianapolis on Saturday night, and it is time to hop straight into your Packers vs Colts predictions for this matchup.
Matchup: Colts vs Packers Overview
- Teams: Green Bay Packers at Indianapolis Colts
- Date: Saturday, August 16th, 2025
- Time: Kickoff is at 1:00 PM EST
- Venue: Lucas Oil Stadium in Indianapolis, Indiana
Current Colts vs Packers Odds
| Indianapolis Colts | Green Bay Packers | |
| Moneyline | -275 | +180 |
| Total | Over 40.5 Points (-120) | Under 40.5 Points (-120) |
The NFL odds have given the Indianapolis Colts a significant edge in this matchup. Home field advantage certainly plays a role, but the bigger factor is the battle at quarterback. Which signal caller plays has a massive impact on the American football odds, and the Colts will roll out either Anthony Richardson or Daniel Jones.
Both are NFL-caliber quarterbacks, and the NFL odds expect the Colts to get the best of the Packers. For the total points, a 40.5 Over/Under is quite high for a preseason matchup, which implies this could be a high-scoring game in Indiana.
Expert Prediction: Who Wins?
Why the Indianapolis Colts Can Win
The Indianapolis Colts will have an advantage at quarterback, whether it is Daniel Jones or Anthony Richardson getting the start. The NFL odds often favor the team with the better quarterback option, and this matchup is no exception. The injury to Jordan Love ensures the Colts will have the better quarterback for every snap of this game, and they are a strong NFL prediction as a result.
One of the primary reasons this is the Colts’ game to lose is their health at receiver. While the Packers are dealing with injuries up and down their roster, the Colts enter this game with a clean bill of health. Michael Pittman Jr. will lead the charge for Indianapolis, and the second preseason game is often when teams start using their starters. The Colts are also playing at home and will want to put on a show for the fans who elect to come out.
While making preseason NFL predictions can have much more variance than the regular season, the Colts have the potential to make this one look easy. They will struggle to compete with a team like Green Bay in the regular season, but their superior quarterback depth, combined with a healthy offense, will be too much for the Packers to overcome.
Ultimately, they are dominant both on the ground and through the air on offense and could easily score 30+ points in this matchup.
Why the Green Bay Packers Can Win
The Green Bay Packers will be without Jordan Love for the entire preseason as he undergoes a minor thumb surgery. While a missing quarterback is always a concern, Love was unlikely to play much in this relatively meaningless game.
Instead, the Packers will have Malik Willis and Sean Clifford under center. While neither has had a very successful career in the NFL, the battle for the QB2 role will make this a very intense showdown. Green Bay has the physicality in the trenches to make this a real battle, and even average quarterback play will shift the NFL odds in their favor.
One man who must make an impact on offense if the Packers are the correct NFL prediction is Matthew Golden. The talented rookie will get no shortage of chances to shine in this game, and he has been able to thrive when given the opportunity in the past. Golden is already an elite route runner with his agility and speed, making him impossible to slow down in preseason play.
Indianapolis has been notorious for slow starts in the preseason, as they opt to rest their defensive starters to keep them fresh for the upcoming season. Green Bay has the chance to take advantage of that fact, and they are an excellent Colts vs Packers prediction to make at +180 odds.
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How to Make Indianapolis Colts vs Green Bay Packers Picks
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