The NFL preseason week 1 odds have been released, and there are plenty of opportunities to lock in your predictions. The NFL lines for week 1 will be far closer than if these matchups were in the regular season, as teams will elect to rest their stars and give chances to practice squad players on an NFL field.
2024 NFL Preseason Week 1 Odds
Moneyline
| Favorite | Underdog |
| New England Patriots (-350) | Carolina Panthers (+233) |
| New York Giants (-200) | Detroit Lions (+142) |
| Atlanta Falcons (-160) | Miami Dolphins (+114) |
| Pittsburgh Steelers (-123) | Houston Texans (-113) |
| Philadelphia Eagles (-134) | Baltimore Ravens (-105) |
| Washington Commanders (-163) | New York Jets (+116) |
| Chicago Bears (-137) | Buffalo Bills (+100) |
| Las Vegas Raiders (-220) | Minnesota Vikings (+154) |
| Cleveland Browns (-158) | Green Bay Packers (+112) |
| Cincinnati Bengals (-250) | Tampa Bay Buccaneers (+175) |
| Jacksonville Jaguars (-155) | Kansas City Chiefs (+112) |
| Tennessee Titans (-260) | San Francisco 49ers (+180) |
| Seattle Seahawks (-138) | LA Chargers (+100) |
| Arizona Cardinals (-138) | New Orleans Saints (+100) |
| Indianapolis Colts (-138) | Denver Broncos (+100) |
| Dallas Cowboys (-225) | LA Rams (+157) |
NFL Week 1 Odds Analysis
Carolina Panthers at New England Patriots: Thursday, August 8th, 7 PM EST
The Carolina Panthers will be big underdogs against the New England Patriots, and the Panthers to cover the +6.5 point spread is one of the strongest NFL preseason odds week 1 predictions to make. The quarterback play for the Patriots will be strong, but this is far too many points for a preseason matchup.
Detroit Lions at New York Giants: Thursday, August 8th, 7 PM EST
The New York Giants are a big favorite on the NFL preseason lines week 1. They have the squad depth to challenge the Lions and will be able to win this game. The Giants love to play their starters in the first week of preseason play, and this year will be no exception.
Atlanta Falcons at Miami Dolphins: Friday, August 9th, 7 PM EST
Based on the NFL preseason week 1 lines, the Falcons are favorites to win, and their rising star quarterback will be the center of attention. Michael Penix Jr. will be sitting on the bench for most of the regular season, but expect him to play his heart out in the preseason. The Falcons will not only win the game but cover the -2.5 point spread in the process.
Houston Texans at Pittsburgh Steelers: Friday, August 9th, 7 PM EST
The Steelers have become much smaller favorites on the NFL odds preseason week 1, but their strong pair of quarterbacks will carry them to victory. Justin Fields and Russell Wilson will battle for the QB1 position, and both men will be desperate to put on a good showing in an otherwise meaningless game.
Philadelphia Eagles at Baltimore Ravens: Friday, August 9th, 7:30 PM EST
The Baltimore Ravens had their historic preseason win streak snapped last year, and this is a great time to make a free prediction on their victory. They are small underdogs against the Eagles on the NFL preseason week 1 lines, but their historic preseason dominance will shine through once again. Expect lots of practice squad players, but the Ravens’ winning mentality will prevail regardless of who takes the field.
Washington Commanders at New York Jets: Saturday, August 10th, 12 PM EST
The Washington Commanders are road favorites in this one, as they will have a serious advantage at quarterback. Number two draft pick Jayden Daniels has been announced as the starter, while the Jets will not allow Aaron Rodgers anywhere near the field. That is enough to get the win, as the Commanders build a big first-half lead.
Chicago Bears at Buffalo Bills: Saturday, August 10th, 1 PM EST
The Bears and Bills have little to play for here, as their rosters are mostly locked in. This is one of the games to avoid this week.
Las Vegas Raiders at Minnesota Vikings: Saturday, August 10th, 4 PM EST
The Minnesota Vikings made the questionable decision to name Sam Darnold as their starting quarterback, and there are simply too many question marks to trust them here. They are +154 underdogs for a reason, as the Raiders strong defensive line will give whoever is under center real problems for the Vikings.
Green Bay Packers at Cleveland Browns: Saturday, August 10th, 4:25 PM EST
The Packers have the stronger squad here, and their practice squad players will pull off the upset win as +112 underdogs. A road game in Cleveland is never easy, but the Packers are a solid underdog pick on the NFL preseason week 1 lines.
Tampa Bay Buccaneers at Cincinnati Bengals: Saturday, August 10th, 7 PM EST
The Bengals will want to get Joe Burrow back into rhythm, but he will not play the full game in his first appearance since his season-ending injury last season. The Bengals -250 odds feel like a trap, and the Buccaneers +4.5 spread pick looks to be the way to go.
San Francisco 49ers at Tennessee Titans: Saturday, August 10th, 7PM EST
The 49ers are one of the deepest teams in the NFL, and their +168 underdog price is one of the biggest surprises on the NFL preseason line week 1.
Kansas City Chiefs at Jacksonville Jaguars: Saturday, August 10th, 7 PM EST
The Chiefs do not care about preseason play, while the Jaguars will be desperate to avenge their defeat last season. Teams always play a little extra harder against the Chiefs, and that trend will remain true even in the preseason.
Seattle Seahawks at Los Angeles Chargers: Saturday, August 10th, 7:05 PM EST
It’s too close to call. There are lots of other options on the NFL preseason odds for week 1, and this game should be avoided.
New Orleans Saints at Arizona Cardinals: Saturday, August 10th, 8 PM EST
The Arizona Cardinals are looking to start the next chapter of their franchise, and a victory against the Saints would be a good place to start. Kyler Murray is unlikely to make a big impact, but at +100 odds, the Cardinals are a strong prediction to make.
Denver Broncos at Indianapolis Colts, Sunday, August 11th, 1 PM EST
The Broncos are an absolute dumpster fire, and they will be unable to move the ball on offense against the Colts. Their lack of offense makes Indianapolis the easy prediction to make in this preseason affair.
Dallas Cowboys at Los Angeles Rams, Sunday, August 11th, 4:30 PM EST
The Cowboys are one of those teams that love winning meaningless games. Their impactful victories haven’t been bountiful in the last few decades, but expect them to bring their A-game in pre-week 1.
