The college football picks for week 10 of the NCAA season are here. The expanded 12-team playoff format is just two months away from being implemented, and these are critical upcoming games for all 25 ranked college football teams. The NCAAF picks reflect the extra urgency for the playoff hopefuls, as any team currently ranked in the top 25 still has a legitimate chance at postseason qualification.
There is no doubt about the best place to make your college football picks, and that is Sportzino. You can make free NCAAF picks on every single week 10 matchup. Not only are there odds for your NCAA football picks against the spread, but there are also moneylines, totals, and player props for your NCAA football picks. The most popular method of making college football predictions is by making NCAA football picks against the spread. In the modern era of college football, the best teams often have lopsided moneyline odds against unranked opposition.
Top 5 College Football Expert Picks Week 10
(#4) Ohio State at (#3) Penn State
- Spread: Ohio State -3.5, Penn State +3.5
- Moneyline: Ohio State -200, Penn State +150
- Over/Under: 45 Points
- Time: Saturday, November 2nd, 12:00 PM EST
The best college football game of the week takes place between number 4 ranked Ohio State and number 3 ranked Penn State. The college football point spread is very close, making either side a respectable college football pick against the spread. Ohio State already has a loss this season, but that was against #1 ranked Oregon. Their ability to score dozens of points in the blink of an eye has made Ohio State a road favorite against the undefeated Penn State. Penn State’s quarterback Drew Allar is currently a game time decision due to injury, which is why Penn State is not the favorite in this week 10 matchup. Regardless of whether or not Allar suits up, Penn State is the best college football prediction to make. If Allar is remotely healthy, he will demand the start in this high profile matchup. These college football odds are too good to pass up, as Penn State will use their home-field advantage to pull out a gutsy victory.
Pick: Penn State Moneyline +150
Looking for more expert picks? Check out our full College football predictions week 9 breakdown
(#19) Ole Miss at Arkansas
- Spread: Ole Miss -6.5, Arkansas +6.5
- Moneyline: Ole Miss -280, Arkansas +200
- Over/Under: 53.5 Points
- Time: Saturday, November 2nd, 12:00 PM EST
Arkansas is a school known for bringing physical football onto the field regardless of the opponent. Ole Miss will be no exception as the Razorbacks look to make a late season playoff push. Ole Miss has already lost two games this season and is lucky to still be ranked inside the top 20. A home defeat to a physical Kentucky side a few weeks ago makes it puzzling to see them as substantial favorites on the college football spread. This is exactly the type of game Arkansas has won in recent years, and they will at least keep it close at home in week 10.
Pick: Arkansas +6.5 (-115)
(#1) Oregon at Michigan
- Spread: Oregon -15.5, Michigan +15.5
- Moneyline: Oregon -1000, Michigan +525
- Over/Under: 45.5 Points
- Time: Saturday, November 2nd, 3:30 PM EST
Oregon looks to keep a firm grasp on the top spot in the college football rankings, and they are an excellent pick to do so. Their ability to play lockdown defense has allowed them to shut down offenses all season long, and Michigan has struggled through the air this year. Michigan is usually ranked at this stage of the season, but a trio of losses to #5 Texas, #24 Illinois, and unranked Washington have seen them drop out of the top 25. They will struggle to pull off the upset against Oregon, but their strong defense can keep this game close. The -15.5 college football point spread in favor of Oregon is fair, but this total is too high. This will be a defensive battle, and the two teams staying under the 45.5 point total is the best college football pick for this week 10 matchup.
Pick: Under 45.5 Points -120
(#10) Texas A&M at South Carolina
- Spread: Texas A&M -2.5, South Carolina +2.5
- Moneyline: Texas A&M -140, South Carolina +105
- Over/Under: 44.5 Points
- Time: Saturday, November 2nd, 7:30 PM EST
Seeing Texas A&M as a short favorite on the college football point spread is shocking. They have been playing consistent football on both sides of the field this season, while South Carolina has been inconsistent. South Carolina has lost all three of their previous games against ranked opponents this season, and they will do so again here. Rather than taking the spread, the Texas A&M moneyline is the better NCAAF pick to make.
Pick: Texas A&M Moneyline -140
Kentucky at (#7) Tennessee
- Spread: Kentucky +16.5, Tennessee -16.5
- Moneyline: Kentucky +500, Tennessee -1100
- Over/Under: 45.5 Points
- Time: Saturday, November 2nd, 7:45 PM EST
The 7th-ranked Tennessee Volunteers are fully rested after their bye week and still have the momentum from a big win against Alabama a few weeks ago. Kentucky has been on the wrong end of some heavy defeats this season and has lost three straight games. Their inability to play defense will not only allow Tennessee to put points on the board, but they will not generate the turnovers they need to pull off an upset. Tennessee quarterback Nico Iamaleava will do the bulk of the heavy lifting early on before the Volunteer second stringers finish the job in the fourth quarter.
Pick: Tennessee Volunteers -16.5 (-120)
