One of the best weeks of the season is in the books, and it’s time to turn the page to our NFL Week 12 predictions, with NFL odds from Sportzino’s free sportsbook.
From a Thursday Night Football clash between two AFC playoff hopefuls to a packed Sunday, the NFL predictions for Week 12 are full of promised drama. With live sports odds to unpack across the board, you don’t want to miss this week’s picks.
Ahead of kickoff on Thursday night, check out all of our NFL Week 12 predictions and picks.
NFL Week 12 Predictions and Picks
Game 1: Steelers at Bears
- Spread: Bears -3.5 (+100)
- Moneyline: Steelers +125/Bears -175
- Over/Under: 45.5 (-115)
- Time: Sunday, November 23 at 1:00 p.m. ET
The Chicago Bears have made a habit of winning tight games and in unpredictable ways, but that sort of magic is not sustainable—and regression looms over them like a spectre for anyone tracking NFL odds.
At home to the Pittsburgh Steelers, who may be without Aaron Rodgers after the veteran broke his non-throwing wrist in Week 11, a letdown spot awaits.
Already this season, the Steelers’ defense put on a masterclass in stumping the previously unstoppable Indianapolis Colts’ offense. Though Bears head coach Ben Johnson has done all he can to give sophomore quarterback Caleb Williams the answers this year, Williams is still a passer who can be confused and get out of rhythm.
Pittsburgh’s defense can put together a kind of showing that will unravel Williams, and a hurried Williams is not a winning player.
Pick: Steelers moneyline (+125)
Game 2: Patriots at Bengals
- Spread: Patriots -7.5 (-120)
- Moneyline: Patriots -400/Bengals +260
- Over/Under: 50.5 (-120)
- Time: Sunday, November 23 at 1:00 p.m. ET
The Cincinnati Bengals, amid a lost season, had reason to be motivated. Joe Burrow publicly announced his intention to return—ahead of schedule—and to help guide the Bengals to the playoffs in a wide-open division.
But that wasn’t enough for a Bengals team that simply failed to show up on Sunday, with a loss to the Steelers likely sufficient to end playoff hopes.
Now, they’ll be without Ja’Marr Chase—who got himself suspended for spitting on Pittsburgh corner Jalen Ramsey—for a meeting against a great AFC outfit in the New England Patriots, a development that will almost certainly influence how traders adjust live sports odds throughout the game.
Under Mike Vrabel, the Pats have resumed being a team that beats up on bad teams—and these Bengals are bad. Cincinnati has allowed 27 points or more in nine straight games, and without Chase, it won’t score enough to keep it close.
New England should clear this line with ease.
Pick: Patriots -7.5 (-120)
Game 3: Giants at Lions
- Spread: Lions -10.5 (-125)
- Moneyline: Giants +400/Lions -750
- Over/Under: 49.5 (-120)
- Time: Sunday, November 23 at 1:00 p.m. ET
Not for the first time in the 2025 season, the Detroit Lions’ offense was muted in Week 11—despite the fanfare around head coach Dan Campbell’s overtaking of play-calling duties.
Though the Lions will surely be helped by a return to the cozy confines of Ford Field, these Lions are no longer the walking Over that the ‘24 version was.
That notion looms even larger with the New York Giants’ defensive line, led by Abdul Carter, Dexter Lawrence, and Brian Burns, across from Jared Goff. A hurried Goff is not an efficient Goff, and efficiency is what is needed to hit the Over here.
For the Giants’ part, whether it’s Jaxon Dart or Jameis Winston, this offense simply doesn’t have the weapons to produce offense at a decently high level. Without Malik Nabers or even Cam Skattebo, it’s a patched-together unit.
Against a Detroit defense playing at a high level, New York will find itself in a rock fight without the requisite ammo to win.
Pick: Under 49.5 (-120)
- You might also like: NFL Week 11 Predictions
NFL Player Prop Predictions: Vikings at Packers
- Spread: Packers -6.5 (-120)
- Moneyline: Vikings +215/Packers -320
- Over/Under: 41.5 (-120)
- Time: Sunday, November 23 at 1:00 p.m. ET
The Green Bay Packers and quarterback Jordan Love are running out of weapons, a reality every sportsbook will likely factor into its projections.
Jayden Reed is nearing a return, but not quite yet ready to hit the field. Tucker Kraft has been lost for the season due to a torn ACL. And, now, running back Josh Jacobs is dealing with a knee injury.
Enter Christian Watson. The dynamic, oft-injured wideout has given Green Bay’s passing attack a much-needed shot in the arm since making his season debut. The last four games have seen him average 4.25 targets per game for a modest line of three catches and 58.5 yards per game.
It’s the yards, however, that matter—Watson’s dynamic downfield ability is not something the Packers can find elsewhere on their roster, especially while Reed remains out.
Finding themselves in a war of attrition, Green Bay will need to manufacture more touches for Watson, which means pushing him downfield more and more. It may just come on a single explosive play or two, but expect Watson to top his yardage total on Sunday.
Pick: Christian Watson Over 48.5 Receiving Yards (-115)
Projected Outcome: Watson ends with 55–70 yards on 4–6 targets.
NFL Against the Spread Predictions: Baltimore Ravens at Los Angeles Chargers
Monday, November 25h, 8:15 PM EST
- Moneyline: Ravens -160, Chargers +125
- Spread: Baltimore Ravens (-2.5)
- Total: 50.5 Points
The Chargers defense has been able to clamp down this season, but that will not be the case against a potent Ravens offense. Derrick Henry and Lamar Jackson have proven to be unstoppable, and the Chargers don’t have enough offensive weapons to consistently respond. The -2.5 point spread is very reasonable for the 2024 NFL week 12 odds, and the Ravens to not only win but cover the spread is a great against-the-spread prediction this week.
Pick: Baltimore Ravens (-2.5) -135
NFL Score Predictions: Colts at Chiefs
- Spread: Chiefs -3.5 (-115)
- Moneyline: Colts +135/Chiefs -190
- Over/Under: 50.5 (-120)
- Time: Sunday, November 23 at 1:00 p.m. ET
One of the most efficient offenses in league history returns off a bye week this Sunday, as the Indianapolis Colts hit the field fresh against a wounded Kansas City Chiefs team.
It’s a pivotal time for the Colts’ season, with a lethargic showing in Germany and an uncharacteristically poor game against the Steelers in their recent games.
For those who believe in these Colts, however, it’s a time to emphasize that belief. Against a proud Chiefs team with their backs against the wall, Indy is going to need to deliver its highest level of performance or face a multi-score loss.
This is a Colts team that can, and has, answered the call. In one of Sunday’s best matchups, expect Daniel Jones, Jonathan Taylor, and company to answer the call yet again.
Pick: Colts Over 2.5 Total Touchdowns (+105)
Projected Outcome: Indy scores 3–4 TDs (passing + rushing mix).
NFL Moneyline Predictions: Jaguars at Cardinals
- Spread: Jaguars -2.5 (-125)
- Moneyline: Jaguars -160/Cardinals +115
- Over/Under: 47.5 (-120)
- Time: Sunday, November 23 at 1:00 p.m. ET
Even with questions around the Jacksonville Jaguars’ quality and the notion of home-field advantage for the Arizona Cardinals, this is a surprisingly small margin on the board.
The Jags are, at worst, middling. The Cardinals are downright bad—and playing shorthanded without Kyler Murray and Marvin Harrison Jr.
There isn’t too much to unpack here. Jacksonville’s moneyline is short enough to offer worthwhile value. Add in the fact Arizona is a lowly team, seemingly sinking lower toward the bottom of the league, and the Jags moneyline becomes an enticing proposition.
Pick: Jaguars moneyline (-160)
NFL Against the Spread Predictions: Browns at Raiders
- Spread: Raiders -3.5 (+100)
- Moneyline: Browns +130/Raiders -180
- Over/Under: 37.5 (-120)
- Time: Sunday, November 23 at 4:05 p.m. ET
A similar string of logic is at play here as is in play in Arizona, albeit with a weaker favorite. The Cleveland Browns are among the league’s worst teams, and with a woeful starter in Dillon Gabriel in concussion protocol, they may have to turn it over to an even worse option in Shedeur Sanders.
Either way, they don’t have the quality to hang even with mediocrity, which they’ll see Sunday against the Las Vegas Raiders. While not a ringing endorsement of the Raiders, a damning indictment of the Browns is not a risk—count on Vegas to cover at home.
Pick: Raiders -3.5 (+100)
